Sample Type

Cancer	Type	Gene	Position	HAZARD RATIO	n With Hotspot	n Without Hotspot	Transcript	pValorate	pLogRank	pCoxHotSpot	pCoxExtendido	pCoxClinico	pCoxMutCount	p HS cox	p HS cox Ext	p HS cox Clinic	p HS cox Mutation Count	qValorate	qLogRank	qCoxHotSpot	qCoxExtendido	qCoxClinico	q HS cox	q HS cox Ext	q HS cox Clinic	q HS cox Mutation Count

The information about the colums shown in the Hotspot table are:

Cancer	Official TCGA study abbreviations
Type	Sample type codes from TCGA
Gene	Official gene symbol
Position	Amino acid position
Hazard Ratio	Hazard Ratio from Extended Cox Model
n with Hotspot	Number of patients with Hotspot
N without Hotspot	Number of patients without Hotspot
pValorate	The p value of the VALORATE statistical test
pLogRank	The p value of the Log Rank statistical test
Transcript	Ensembletranscript code
p HS cox	The p value of the hotspot in the cox model
p HS cox Ext	The p value of the hotspot in the extended cox model
p HS cox Clinic	The p value of the hotspot in the clinic cox model
p HS cox Mutation Count	The p value of the hotspot in the Mutation cox model
qValorate	The false discovery rate (FDR) correction of the p-value of pVALORATE
qLogRank	The false discovery rate (FDR) correction of the p-value of pLogRank
q HS cox	The false discovery rate (FDR) correction of the p-value of pHScox
q HS cox Ext	The false discovery rate (FDR) correction of the p-value of pHScoxExtendido
q HS cox Clinic	The false discovery rate (FDR) correction of the p-value of pHScoxClinico
q HS cox Mutation Count	The false discovery rate (FDR) correction of the p-value of pHScoxMutCount

Test 1: Patients-Hotspots (Hotspots vs Other hotspots)

The patients carrying a hotspot mutation are compared versus the patients carrying other hotspots in the same gene (for the same cancer type).

Test 2: Patients-Gene (Hotspot vs Other mutations)

The patients carrying a hotspot mutation are compared versus the patients carrying other mutations in the same gene (for the same cancer type).

The patients carrying a hotspot mutation are compared versus all other patients (for the same cancer type).

The patients carrying a hotspot mutation are compared versus the patients carrying other hotspot in the same gene (for the same cancer type).

Inspired on: Ponder Referencia al paper con liga al pmid