CoGTEx: Unscaled coexpression estimation from GTEx data forecast novel functional gene partners

Welcome to CoGTEX!

Coexpression estimations are helpful for many purposes, including analysis of pathways, cofactors, regulators, targets, and human health and disease. Ideally, coexpression estimations should consider as many diverse cell types as possible and consider that available data is not uniform across tissues. Importantly, the coexpression estimations available today are performed on a “tissue level”, which is based on cell type standardized or scaled formulations, and little or no attention is paid to overall gene expression levels. This tissue - level estimation assumes that variance expression levels are more important than mean expression levels. Here, we challenge this assumption by estimating coexpression without scaling named “system level” and show that it prov ides valuable information. We made available a resource to view, download, and analyze tissue - and system - level coexpression estimations from GTEx human data.